Water-Soluble Anisotropic Iron Oxide Nanoparticles: Dextran-Coated Crystalline Nanoplates and Nanoflowers
نویسندگان
چکیده
We report a simple phase transfer based synthesis route for two novel anisotropic water soluble iron oxide nanoparticle shapes, namely, nanoplates and nanoflowers. The nanoplates and nanoflowers are initially prepared in an organic solvent via a modified ‘‘heat-up’’ method. Then, the crystalline nanoparticles are rendered hydrophilic via sonication in the presence of dextran and water. These nanoparticles are highly monodisperse and superparamagnetic at room temperature. High resolution transmission electron microscopy indicates that the iron oxides cores are not affected by the phase transfer. Dextran coating is confirmed by dynamic light scattering, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The obtained dextran coverage was 26wt% for the nanoplates and 37wt% for the nanoflowers. The nanoplates and nanoflowers were not only water soluble, but also remained stable at different pH (4–7) and in common aqueous buffer solutions. Thorough characterizations of the nonspherical iron oxide nanoparticles indicate that these particles could be useful for potential biomedical applications and magnetic resonance imaging.
منابع مشابه
Controlled synthesis of iron oxide nanoplates and nanoflowers.
An effective approach to synthesizing crystalline iron oxide nanoplates (~3 nm thick) and nanoflowers composed of ~5 nm small grains was reported. The formation of different-shaped nanoparticles in a similar system was achieved by controlling the nucleus concentration and growth rate.
متن کاملPreparation and characterization of PEG/Dextran coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical applications
Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. Here we appliedcathodic electrochemical deposition (CED) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (SPIONs). In first step, bare Fe3O4 n...
متن کاملThe Cytotoxicity of Dextran-coated Iron Oxide Nanoparticles on Hela and MCF-7 Cancerous Cell Lines
Background: Recently, iron oxide nanoparticles have attracted attention in various diagnosis and treatment fields. The aim of the present study was to investigate the cytotoxicity of various concentrations and incubation times of dextran-coated iron oxide nanoparticles (DIONPs) on HeLa and MCF-7 cancerous cell lines. Methods: This in-vitro study was conducted at Pharmaceutical Sciences Researc...
متن کاملPreparation and characterization of PEG/Dextran coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical applications
Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. Here we appliedcathodic electrochemical deposition (CED) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (SPIONs). In first step, bare Fe3O4 n...
متن کاملDetection of Her2 Levels in Cancerous Cells Based on Iron Oxide Nanoparticles
In this study, we synthesized Herceptin conjugated magnetic nanoparticles (HMNs) as an alternative probe to discover the levels of HER2 (Human epidermal growth factor receptor-2) in the surface of cells. These nanoparticles can be used by magnetic resonance imaging (MRI) (non-invasive methods) for screening the patients with HER2 positive or negative tumors. Dextran coated iron oxide nanopartic...
متن کامل